Assay Detail
Functional
CHEMBL760815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 6.91 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 8.80 |
| CHEMBL65079 | — | — | 1 | 7.58 |
| CHEMBL115174 | — | — | 1 | 7.37 |
| CHEMBL64123 | — | — | 1 | 7.35 |
| CHEMBL114435 | — | — | 1 | 7.34 |
| CHEMBL333167 | — | — | 1 | 7.31 |
| CHEMBL114553 | — | — | 1 | 7.24 |
| CHEMBL113099 | — | — | 1 | 7.16 |
| CHEMBL67362 | — | — | 1 | 7.15 |
| CHEMBL294116 | — | — | 1 | 7.12 |
| CHEMBL112058 | — | — | 1 | 7.12 |
| CHEMBL114611 | — | — | 1 | 6.73 |
| CHEMBL114607 | — | — | 1 | 6.51 |
| CHEMBL325213 | — | — | 1 | 6.46 |
| CHEMBL115173 | — | — | 1 | 6.43 |
| CHEMBL321243 | — | — | 1 | 6.27 |
| CHEMBL8639 | — | — | 1 | 6.25 |
| CHEMBL325221 | — | — | 1 | 6.00 |
| CHEMBL332264 | — | — | 1 | 5.17 |
| CHEMBL286446 | — | — | 1 | - |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | - |
| CHEMBL116221 | — | — | 1 | - |
| CHEMBL116007 | — | — | 1 | - |
| CHEMBL112987 | — | — | 1 | - |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | - |
| CHEMBL326092 | — | — | 1 | - |
| CHEMBL322108 | — | — | 1 | - |
| CHEMBL114941 | — | — | 1 | - |
| CHEMBL113098 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908373 | ONAPRISTONE | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL65079 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL115174 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL64123 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL114435 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL333167 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL114553 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL113099 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL67362 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL294116 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL112058 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL114611 | — | EC50 | = | 187.0 | nM | 6.73 |
| CHEMBL114607 | — | EC50 | = | 307.0 | nM | 6.51 |
| CHEMBL325213 | — | EC50 | = | 345.0 | nM | 6.46 |
| CHEMBL115173 | — | EC50 | = | 375.0 | nM | 6.43 |
| CHEMBL321243 | — | EC50 | = | 538.0 | nM | 6.27 |
| CHEMBL8639 | — | EC50 | = | 561.0 | nM | 6.25 |
| CHEMBL325221 | — | EC50 | = | 997.0 | nM | 6.00 |
| CHEMBL332264 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL286446 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | EC50 | > | 10000.0 | nM | - |
| CHEMBL116221 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL116007 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL112987 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL103 | PROGESTERONE | EC50 | > | 10000.0 | nM | - |
| CHEMBL326092 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL322108 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL114941 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL113098 | — | EC50 | > | 10000.0 | nM | - |