Assay Detail
Binding
CHEMBL760825
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant bovine adrenal cortex Phosphodiesterase 2 (PDE2)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Adrenal cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL3477) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.10 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68152 | — | — | 1 | 5.82 |
| CHEMBL431377 | — | — | 1 | 5.75 |
| CHEMBL308249 | — | — | 1 | 5.68 |
| CHEMBL305618 | — | — | 1 | 5.51 |
| CHEMBL70569 | — | — | 1 | 4.96 |
| CHEMBL18745 | — | — | 1 | 4.92 |
| CHEMBL305617 | — | — | 1 | 4.92 |
| CHEMBL278644 | — | — | 1 | 4.47 |
| CHEMBL305988 | — | — | 1 | 4.46 |
| CHEMBL304161 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68152 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL431377 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL308249 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL305618 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL70569 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL18745 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL305617 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL278644 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL305988 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL304161 | — | IC50 | = | 35000.0 | nM | 4.46 |