Assay Detail
Binding
CHEMBL760835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphodiesterase 6 from bovine retina
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5(')-sulfonamide moiety of phenyl ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.15 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245317 | — | — | 1 | 8.59 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245317 | — | IC50 | = | 2.58 | nM | 8.59 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 19.77 | nM | 7.70 |