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Assay Detail

CHEMBL760838

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against bovine retina phosphodiesterase 6 activity
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Retina
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Phosphodiesterase 6 (CHEMBL2096979)
Type PROTEIN FAMILY
Organism Bos taurus

Publication

8-Aryl xanthines potent inhibitors of phosphodiesterase 5.
Arnold R, Beer D, Bhalay G, Baettig U, Collingwood SP, Craig S, Devereux N, Dunstan A, Glen A, Gomez S, Haberthuer S, Howe T, Jelfs S, Moser H, Naef R, Nicklin P, Sandham D, Stringer R, Turner K, Watson S, Zurini M.
Bioorg Med Chem Lett (2002) 12 : 2587 -2590
PubMed 12182866 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 7.00 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL315477 1 8.52
CHEMBL87202 2 8.22
CHEMBL327772 1 7.85
CHEMBL314849 1 7.82
CHEMBL433418 1 7.80
CHEMBL86512 1 7.77
CHEMBL313197 1 7.43
CHEMBL314891 1 7.17
CHEMBL316372 1 7.14
CHEMBL86785 1 7.11
CHEMBL89248 1 7.08
CHEMBL87901 1 7.06
CHEMBL89670 1 7.04
CHEMBL85350 1 7.00
CHEMBL86578 1 6.99
CHEMBL86673 1 6.84
CHEMBL89151 1 6.69
CHEMBL314667 1 6.67
CHEMBL87304 1 6.66
CHEMBL410057 1 6.64
CHEMBL90164 1 6.62
CHEMBL87777 1 6.46
CHEMBL87954 1 6.36
CHEMBL89239 1 5.94
CHEMBL84731 1 5.92
CHEMBL86743 1 5.62
CHEMBL86602 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL315477 IC50 = 3.0 nM 8.52
CHEMBL87202 IC50 = 6.0 nM 8.22
CHEMBL87202 IC50 = 6.0 nM 8.22
CHEMBL327772 IC50 = 14.0 nM 7.85
CHEMBL314849 IC50 = 15.0 nM 7.82
CHEMBL433418 IC50 = 16.0 nM 7.80
CHEMBL86512 IC50 = 17.0 nM 7.77
CHEMBL313197 IC50 = 37.0 nM 7.43
CHEMBL314891 IC50 = 68.0 nM 7.17
CHEMBL316372 IC50 = 73.0 nM 7.14
CHEMBL86785 IC50 = 77.0 nM 7.11
CHEMBL89248 IC50 = 83.0 nM 7.08
CHEMBL87901 IC50 = 87.0 nM 7.06
CHEMBL89670 IC50 = 91.0 nM 7.04
CHEMBL85350 IC50 = 100.0 nM 7.00
CHEMBL86578 IC50 = 102.0 nM 6.99
CHEMBL86673 IC50 = 146.0 nM 6.84
CHEMBL89151 IC50 = 203.0 nM 6.69
CHEMBL314667 IC50 = 214.0 nM 6.67
CHEMBL87304 IC50 = 217.0 nM 6.66
CHEMBL410057 IC50 = 227.0 nM 6.64
CHEMBL90164 IC50 = 242.0 nM 6.62
CHEMBL87777 IC50 = 345.0 nM 6.46
CHEMBL87954 IC50 = 436.0 nM 6.36
CHEMBL89239 IC50 = 1150.0 nM 5.94
CHEMBL84731 IC50 = 1210.0 nM 5.92
CHEMBL86743 IC50 = 2380.0 nM 5.62
CHEMBL86602 IC50 = 5600.0 nM 5.25