Assay Detail
Binding
CHEMBL760876
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Inhibitory activity against procollagen C-Proteinase (PCP).
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: solid-phase synthesis of ornithine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 6.26 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279023 | — | — | 1 | 8.41 |
| CHEMBL21486 | — | — | 1 | 8.05 |
| CHEMBL21073 | — | — | 1 | 7.62 |
| CHEMBL303373 | — | — | 1 | 7.42 |
| CHEMBL303082 | — | — | 1 | 7.35 |
| CHEMBL63503 | — | — | 1 | 7.35 |
| CHEMBL63225 | — | — | 1 | 7.30 |
| CHEMBL303343 | — | — | 1 | 7.30 |
| CHEMBL63620 | — | — | 1 | 7.26 |
| CHEMBL291796 | — | — | 1 | 7.24 |
| CHEMBL430941 | — | — | 1 | 7.11 |
| CHEMBL65207 | — | — | 1 | 7.04 |
| CHEMBL62908 | — | — | 1 | 7.01 |
| CHEMBL305227 | — | — | 1 | 7.01 |
| CHEMBL294344 | — | — | 1 | 6.96 |
| CHEMBL294783 | — | — | 1 | 6.92 |
| CHEMBL294041 | — | — | 1 | 6.85 |
| CHEMBL302164 | — | — | 1 | 6.80 |
| CHEMBL62614 | — | — | 1 | 6.80 |
| CHEMBL293010 | — | — | 1 | 6.77 |
| CHEMBL307349 | — | — | 1 | 6.66 |
| CHEMBL302674 | — | — | 1 | 6.58 |
| CHEMBL63685 | — | — | 1 | 6.54 |
| CHEMBL291863 | — | — | 1 | 6.11 |
| CHEMBL417030 | — | — | 1 | 6.04 |
| CHEMBL63368 | — | — | 1 | 6.01 |
| CHEMBL65077 | — | — | 1 | 6.00 |
| CHEMBL65566 | — | — | 1 | 5.85 |
| CHEMBL302779 | — | — | 1 | 5.80 |
| CHEMBL65023 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279023 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL21486 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL21073 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL303373 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL303082 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL63503 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL63225 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL303343 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL63620 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL291796 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL430941 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL65207 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL305227 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL62908 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL294344 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL294783 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL294041 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL302164 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL62614 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL293010 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL307349 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL302674 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL63685 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL291863 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL417030 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL63368 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL65077 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL65566 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL302779 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL65023 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL305129 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL65382 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL63252 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL65972 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL66422 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL63344 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL65203 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL304575 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL65451 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL63675 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL293848 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL66263 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL63488 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL66144 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL305572 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL63287 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL418674 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL292267 | — | IC50 | = | 61000.0 | nM | 4.21 |