Compound Detail
CHEMBL279023
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COc1ccc(S(=O)(=O)N(Cc2ccc3c(c2)OCO3)[C@H](CCCNC(=O)OCc2ccccc2Cl)C(=O)NO)cc1
Basic Information
| ChEMBL ID | CHEMBL279023 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GDPDEHNSRMALGQ-XMMPIXPASA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
620.1
MW (Da)
3.85
ALogP
9
HBA
3
HBD
152.7
PSA (Ų)
0.15
QED
1
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bone morphogenetic protein 1 CHEMBL3898 | IC50 | 8.41 | 8.41 | 3.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bone morphogenetic protein 1 | IC50 | = | 3.9 | nM | 8.41 | Inhibitory activity against procollagen C-Proteinase (PCP). | 11514144 |
| Bone morphogenetic protein 1 | IC50 | = | 3.9 | nM | 8.41 | Inhibitory activity against Procollagen C-Proteinase (PCP) | 11934595 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11514144 | 10.1016/s0960-894x(01)00384-5 | Bone morphogenetic protein 1 | 1 |
| 11934595 | 10.1016/s0960-894x(02)00117-8 | Bone morphogenetic protein 1 | 1 |
Data from ChEMBL 36 via Core Engine