Assay Detail
Binding
CHEMBL760877
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Inhibitory activity against Procollagen C-Proteinase (PCP)
43
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.50 | 10.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21249 | — | — | 1 | 10.62 |
| CHEMBL282896 | — | — | 2 | 9.70 |
| CHEMBL279023 | — | — | 1 | 8.41 |
| CHEMBL282484 | — | — | 1 | 8.34 |
| CHEMBL20787 | — | — | 1 | 8.22 |
| CHEMBL21486 | — | — | 1 | 8.05 |
| CHEMBL21237 | — | — | 1 | 7.85 |
| CHEMBL281582 | — | — | 1 | 7.80 |
| CHEMBL276883 | — | — | 1 | 7.75 |
| CHEMBL277252 | — | — | 1 | 7.64 |
| CHEMBL280337 | — | — | 1 | 7.64 |
| CHEMBL21073 | — | — | 1 | 7.62 |
| CHEMBL277469 | — | — | 1 | 7.57 |
| CHEMBL280116 | — | — | 1 | 7.52 |
| CHEMBL20541 | — | — | 1 | 7.50 |
| CHEMBL20484 | — | — | 1 | 7.50 |
| CHEMBL20653 | — | — | 1 | 7.44 |
| CHEMBL283114 | — | — | 1 | 7.43 |
| CHEMBL21766 | — | — | 1 | 7.40 |
| CHEMBL20487 | — | — | 1 | 7.40 |
| CHEMBL21765 | — | — | 1 | 7.35 |
| CHEMBL21657 | — | — | 1 | 7.30 |
| CHEMBL21492 | — | — | 1 | 7.28 |
| CHEMBL21163 | — | — | 1 | 7.28 |
| CHEMBL20435 | — | — | 1 | 7.22 |
| CHEMBL21067 | — | — | 1 | 7.22 |
| CHEMBL21559 | — | — | 1 | 7.16 |
| CHEMBL21387 | — | — | 1 | 7.12 |
| CHEMBL21789 | — | — | 1 | 7.10 |
| CHEMBL21543 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21249 | — | IC50 | = | 0.024 | nM | 10.62 |
| CHEMBL282896 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL282896 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL279023 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL282484 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL20787 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL21486 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL21237 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL281582 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL276883 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL280337 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL277252 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL21073 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL277469 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL280116 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL20541 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL20484 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL20653 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL283114 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL20487 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL21766 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL21765 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL21657 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL21163 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL21492 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL20435 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL21067 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL21559 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL21387 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL21789 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL21543 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL277173 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL22013 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL277846 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL281165 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL21714 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL21182 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL418009 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL436541 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL20780 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL276950 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL20850 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL283328 | — | IC50 | = | 230.0 | nM | 6.64 |