Assay Detail
Binding
CHEMBL760886
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human progesterone 17-alpha-hydroxylase.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The 16,17-double bond is needed for irreversible inhibition of human cytochrome p45017alpha by abiraterone (17-(3-pyridyl)androsta-5, 16-dien-3beta-ol) and related steroidal inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.61 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432751 | — | — | 1 | 8.52 |
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | 8.40 |
| CHEMBL3137967 | — | — | 1 | 8.30 |
| CHEMBL310315 | — | — | 1 | 7.89 |
| CHEMBL357811 | — | — | 1 | 7.57 |
| CHEMBL82926 | — | — | 1 | 7.33 |
| CHEMBL3137965 | — | — | 1 | 7.13 |
| CHEMBL310690 | — | — | 1 | 6.80 |
| CHEMBL2112888 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432751 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL254328 | ABIRATERONE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3137967 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL310315 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL357811 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL82926 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3137965 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL310690 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2112888 | — | IC50 | = | 260.0 | nM | 6.58 |