Assay Detail
Binding
CHEMBL760919
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Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human lung
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.32 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 5.96 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 5.47 |
| CHEMBL19224 | PAPAVERINE | 3.0 | 1 | 5.05 |
| CHEMBL150764 | BUFROLIN | 2.0 | 1 | 4.80 |
| CHEMBL18701 | RO-201724 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL19224 | PAPAVERINE | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL150764 | BUFROLIN | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL18701 | RO-201724 | IC50 | = | 250000.0 | nM | - |