Assay Detail
Binding
CHEMBL760937
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Inhibitory activity against PDE1 from cerebral cortex
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.63 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109574 | — | — | 1 | 4.85 |
| CHEMBL326464 | — | — | 1 | 4.40 |
| CHEMBL12856 | INAMRINONE | 4.0 | 1 | - |
| CHEMBL110304 | — | — | 1 | - |
| CHEMBL111990 | — | — | 1 | - |
| CHEMBL322358 | — | — | 1 | - |
| CHEMBL18701 | RO-201724 | — | 1 | - |
| CHEMBL111486 | — | — | 1 | - |
| CHEMBL108884 | — | — | 1 | - |
| CHEMBL109427 | — | — | 1 | - |
| CHEMBL326285 | — | — | 1 | - |
| CHEMBL111466 | — | — | 1 | - |
| CHEMBL333599 | — | — | 1 | - |
| CHEMBL109550 | — | — | 1 | - |
| CHEMBL320350 | — | — | 1 | - |
| CHEMBL109639 | — | — | 1 | - |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | - |
| CHEMBL111071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109574 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL326464 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL12856 | INAMRINONE | IC50 | > | 300000.0 | nM | - |
| CHEMBL110304 | — | IC50 | = | 149000.0 | nM | - |
| CHEMBL111990 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL322358 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL18701 | RO-201724 | IC50 | > | 300000.0 | nM | - |
| CHEMBL111486 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL108884 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109427 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL326285 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL111466 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL333599 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109550 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL320350 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109639 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1355736 | THEOPHYLLINE | IC50 | = | 356000.0 | nM | - |
| CHEMBL111071 | — | IC50 | > | 100000.0 | nM | - |