Assay Detail
Functional
CHEMBL761003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity against phospholipase C (PLC) was determined in adult rat hippocampal slices
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (CHEMBL4034) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
(2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D-coupled metabotropic glutamate receptors: asymmetric synthesis and preliminary biological properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.25 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34453 | — | — | 1 | 4.30 |
| CHEMBL39221 | — | — | 1 | 4.19 |
| CHEMBL72157 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34453 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL39221 | — | EC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL72157 | — | EC50 | > | 300000.0 | nM | - |