Assay Detail
Functional
CHEMBL761041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of LTB4 formation in human peripheral blood polymorphonuclear leukocytes (HPMN)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.18 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150169 | — | — | 1 | 9.05 |
| CHEMBL88084 | — | — | 1 | 8.92 |
| CHEMBL129292 | — | — | 1 | 8.82 |
| CHEMBL151726 | — | — | 1 | 8.66 |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | 8.52 |
| CHEMBL423835 | ZM-211965 | — | 1 | 8.36 |
| CHEMBL357335 | — | — | 1 | 8.32 |
| CHEMBL151916 | — | — | 1 | 7.96 |
| CHEMBL149839 | — | — | 1 | 7.26 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150169 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL88084 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL129292 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL151726 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL16596 | QUIFLAPON | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL423835 | ZM-211965 | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL357335 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL151916 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL149839 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL93 | ZILEUTON | IC50 | = | 1100.0 | nM | 5.96 |