Assay Detail
Binding
CHEMBL761280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGF receptor autophosphorylation in rat aortic vascular smooth muscle cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor (PDGFr) (CHEMBL2111344) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.37 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301483 | — | — | 1 | 6.62 |
| CHEMBL57347 | — | — | 1 | 6.57 |
| CHEMBL45827 | — | — | 1 | 6.35 |
| CHEMBL56983 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301483 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL57347 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL45827 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL56983 | — | IC50 | = | 1200.0 | nM | 5.92 |