Assay Detail
Functional
CHEMBL761317
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta-hematin formation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Histidine-rich protein PFHRP-II (CHEMBL1923) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.18 | 4.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.42 |
| CHEMBL146945 | — | — | 1 | 4.19 |
| CHEMBL146617 | — | — | 1 | 4.16 |
| CHEMBL148195 | — | — | 1 | 4.15 |
| CHEMBL344105 | — | — | 1 | 4.11 |
| CHEMBL146616 | — | — | 1 | 4.07 |
| CHEMBL148139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL146945 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL146617 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL148195 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL344105 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL146616 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL148139 | — | IC50 | = | 102000.0 | nM | - |