Histidine-rich protein PFHRP-II · SINGLE PROTEIN · Plasmodium falciparum
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As of 2026-09-13Protein identity stays anchored to UniProt P05227. Use UniProt P05227 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P05227 as the stable identity anchor, then attach disease evidence before program review.
Histidine-rich protein PFHRP-II
Review this target as Histidine-rich protein PFHRP-II, mapped to UniProt P05227. Sequence length is 332 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histidine-rich protein PFHRP-II as ChEMBL target CHEMBL1923, mapped to UniProt P05227. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histidine-rich protein PFHRP-II is the right protein anchor across sources, using UniProt P05227 as the stable mapping.
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| Preferred Name | Histidine-rich protein PFHRP-II |
| Target Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
| UniProt | P05227 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histidine-rich protein PFHRP-II |
| UniProt Accession | P05227 |
| Component Type | Protein |
| Sequence Length | 332 aa |
Histidine-rich protein PFHRP-II
Review this target as Histidine-rich protein PFHRP-II, mapped to UniProt P05227. Sequence length is 332 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL356811 | 8.17 | IC50 | 6.7 | Preclinical |
| CHEMBL345958 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL357948 | 7.63 | IC50 | 23.3 | Preclinical |
| CHEMBL2111198 | 7.63 | IC50 | 23.5 | Preclinical |
| CHEMBL153507 | 7.57 | IC50 | 27.1 | Preclinical |
| CHEMBL149751 | 7.47 | IC50 | 34.2 | Preclinical |
| CHEMBL152862 | 7.47 | IC50 | 34.0 | Preclinical |
| CHEMBL357111 | 7.45 | IC50 | 35.6 | Preclinical |
| CHEMBL356005 | 7.43 | IC50 | 37.5 | Preclinical |
| CHEMBL152635 | 7.4 | IC50 | 40.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 67 | 64 | 5.3 |
| organism-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 39 | 6.2 |