Compound Detail
CHEMBL356811
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Basic Information
| ChEMBL ID | CHEMBL356811 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FVWVRVNTEAFOPI-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
474.1
MW (Da)
5.60
ALogP
5
HBA
1
HBD
34.6
PSA (Ų)
0.34
QED
1
Ro5 Violations
15
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histidine-rich protein PFHRP-II CHEMBL1923 | IC50 | 8.17 | 8.17 | 6.7 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 8.12 | 8.12 | 7.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histidine-rich protein PFHRP-II | IC50 | = | 6.7 | nM | 8.17 | In vitro inhibition of beta-hematin formation | 12570376 |
| Plasmodium falciparum | IC50 | = | 7.5 | nM | 8.12 | In vitro antimalarial activity against Plasmodium falciparum FcB1 | 12570376 |
| Plasmodium falciparum | IC50 | = | 7.5 | nM | 8.12 | Antimalarial activity against Plasmodium falciparum FcB1/Columbia erythrocytes i... | 19361896 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12570376 | 10.1021/jm020960r | No relevant target | 2 |
| 12570376 | 10.1021/jm020960r | Plasmodium falciparum | 1 |
| 12570376 | 10.1021/jm020960r | MRC5 | 1 |
| 12570376 | 10.1021/jm020960r | Histidine-rich protein PFHRP-II | 1 |
| 12570376 | 10.1021/jm020960r | Unchecked | 1 |
| 19361896 | 10.1016/j.ejmech.2009.02.024 | Plasmodium falciparum | 1 |
| 19361896 | 10.1016/j.ejmech.2009.02.024 | MRC5 | 1 |
| 19361896 | 10.1016/j.ejmech.2009.02.024 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine