Assay Detail
Functional
CHEMBL820823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of beta-hematin formation
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Histidine-rich protein PFHRP-II (CHEMBL1923) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.45 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356811 | — | — | 1 | 8.17 |
| CHEMBL345958 | — | — | 1 | 7.82 |
| CHEMBL357948 | — | — | 1 | 7.63 |
| CHEMBL2111198 | — | — | 1 | 7.63 |
| CHEMBL153507 | — | — | 1 | 7.57 |
| CHEMBL149751 | — | — | 1 | 7.47 |
| CHEMBL152862 | — | — | 1 | 7.47 |
| CHEMBL357111 | — | — | 1 | 7.45 |
| CHEMBL356005 | — | — | 1 | 7.43 |
| CHEMBL152635 | — | — | 1 | 7.40 |
| CHEMBL151514 | — | — | 1 | 7.40 |
| CHEMBL152392 | — | — | 1 | 7.37 |
| CHEMBL152052 | — | — | 1 | 7.36 |
| CHEMBL152886 | — | — | 1 | 7.32 |
| CHEMBL422682 | — | — | 1 | 7.30 |
| CHEMBL356249 | — | — | 1 | 7.29 |
| CHEMBL152286 | — | — | 1 | 7.21 |
| CHEMBL346177 | — | — | 1 | 7.13 |
| CHEMBL152266 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356811 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL345958 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL357948 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL2111198 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL153507 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL149751 | — | IC50 | = | 34.2 | nM | 7.47 |
| CHEMBL152862 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL357111 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL356005 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL152635 | — | IC50 | = | 40.2 | nM | 7.40 |
| CHEMBL151514 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL152392 | — | IC50 | = | 42.5 | nM | 7.37 |
| CHEMBL152052 | — | IC50 | = | 43.4 | nM | 7.36 |
| CHEMBL152886 | — | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL422682 | — | IC50 | = | 50.6 | nM | 7.30 |
| CHEMBL356249 | — | IC50 | = | 50.9 | nM | 7.29 |
| CHEMBL152286 | — | IC50 | = | 61.4 | nM | 7.21 |
| CHEMBL346177 | — | IC50 | = | 74.9 | nM | 7.13 |
| CHEMBL152266 | — | IC50 | = | 79.0 | nM | 7.10 |