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Assay Detail

CHEMBL761401

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Binding
Binding affinity for human oxytocin receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Oxytocin receptor (CHEMBL2049)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Nonpeptide oxytocin antagonists: analogs of L-371,257 with improved potency.
Williams PD, Bock MG, Evans BE, Freidinger RM, Gallicchio SN, Guidotti MT, Jacobson MA, Kuo MS, Levy MR, Lis EV, Michelson SR, Pawluczyk JM, Perlow DS, Pettibone DJ, Quigley AG, Reiss DR, Salvatore C, Stauffer KJ, Woyden CJ.
Bioorg Med Chem Lett (1999) 9 : 1311 -1316
PubMed 10340620 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 8.03 9.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25353 1 9.07
CHEMBL24456 1 9.00
CHEMBL278818 1 8.85
CHEMBL24526 1 8.85
CHEMBL24682 1 8.62
CHEMBL25120 1 8.35
CHEMBL24781 1 8.03
CHEMBL279230 1 8.01
CHEMBL26877 1 7.48
CHEMBL27157 1 7.06
CHEMBL25611 1 6.62
CHEMBL25502 1 6.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25353 Ki = 0.86 nM 9.07
CHEMBL24456 Ki = 1.0 nM 9.00
CHEMBL278818 Ki = 1.4 nM 8.85
CHEMBL24526 Ki = 1.4 nM 8.85
CHEMBL24682 Ki = 2.4 nM 8.62
CHEMBL25120 Ki = 4.5 nM 8.35
CHEMBL24781 Ki = 9.3 nM 8.03
CHEMBL279230 Ki = 9.8 nM 8.01
CHEMBL26877 Ki = 33.0 nM 7.48
CHEMBL27157 Ki = 87.0 nM 7.06
CHEMBL25611 Ki = 240.0 nM 6.62
CHEMBL25502 Ki = 390.0 nM 6.41