Assay Detail
Binding
CHEMBL761404
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Compound was evaluated for OT receptor affinity by displacement of [3H]OT from binding sites in uterine tissue taken from nonlabor pregnant women
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.25 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112248 | — | — | 1 | 8.89 |
| CHEMBL435021 | — | — | 1 | 8.35 |
| CHEMBL2112249 | — | — | 1 | 8.29 |
| CHEMBL1790937 | — | — | 1 | 8.03 |
| CHEMBL338308 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112248 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL435021 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL2112249 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL1790937 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL338308 | — | Ki | = | 21.0 | nM | 7.68 |