Assay Detail
Binding
CHEMBL761483
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Concentration required to inhibit 50% activity of phosphodiesterase IV isoenzyme (at 100 uM).
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 4.89 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342727 | — | — | 1 | 6.22 |
| CHEMBL145159 | — | — | 1 | 5.82 |
| CHEMBL356323 | CIPAMFYLLINE | 2.0 | 1 | 5.72 |
| CHEMBL436402 | — | — | 1 | 5.52 |
| CHEMBL357851 | — | — | 1 | 5.48 |
| CHEMBL144400 | — | — | 1 | 5.48 |
| CHEMBL142238 | — | — | 1 | 5.43 |
| CHEMBL357921 | — | — | 1 | 5.43 |
| CHEMBL144545 | — | — | 1 | 5.27 |
| CHEMBL423559 | — | — | 1 | 5.19 |
| CHEMBL439809 | — | — | 1 | 5.16 |
| CHEMBL142782 | — | — | 1 | 5.15 |
| CHEMBL144341 | — | — | 1 | 5.15 |
| CHEMBL341866 | — | — | 1 | 5.09 |
| CHEMBL144196 | — | — | 1 | 5.02 |
| CHEMBL144656 | — | — | 1 | 5.01 |
| CHEMBL342998 | — | — | 1 | 5.00 |
| CHEMBL423933 | — | — | 1 | 4.85 |
| CHEMBL144374 | — | — | 1 | 4.85 |
| CHEMBL144940 | — | — | 1 | 4.77 |
| CHEMBL355919 | — | — | 1 | 4.75 |
| CHEMBL357428 | — | — | 1 | 4.70 |
| CHEMBL358296 | — | — | 1 | 4.64 |
| CHEMBL144047 | — | — | 1 | 4.62 |
| CHEMBL142969 | — | — | 1 | 4.62 |
| CHEMBL358574 | — | — | 1 | 4.43 |
| CHEMBL146165 | — | — | 1 | 4.43 |
| CHEMBL145515 | — | — | 1 | 4.39 |
| CHEMBL356928 | — | — | 1 | 4.38 |
| CHEMBL341622 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342727 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL145159 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL356323 | CIPAMFYLLINE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL436402 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL357851 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL144400 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL142238 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL357921 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL144545 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL423559 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL439809 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL142782 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL144341 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL341866 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL144196 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL144656 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL342998 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL144374 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL423933 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL144940 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL355919 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL357428 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL358296 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL144047 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL142969 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL358574 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL146165 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL145515 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL356928 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL341622 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL144978 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL359185 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL356138 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL344720 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL358721 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL142922 | — | IC50 | = | 56000.0 | nM | 4.25 |