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Assay Detail

CHEMBL761494

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of carbachol-induced release of alpha-amylase from pancreatic acini from rat was determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Intermediate

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent.
Carroll FI, Abraham P, Parham K, Griffith RC, Ahmad A, Richard MM, Padilla FN, Witkin JM, Chiang PK.
J Med Chem (1987) 30 : 805 -809
PubMed 3494849 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 7.52 10.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL287868 AZAPROPHEN 1 10.17
CHEMBL26505 APROFENE 2.0 1 7.96
CHEMBL12980 QUINUCLIDINYL BENZILATE 1 7.68
CHEMBL70352 BENACTYZINE 2.0 1 7.52
CHEMBL517712 ATROPINE 4.0 1 7.29
CHEMBL353846 ADIPHENINE 2.0 1 6.46
CHEMBL9967 PIRENZEPINE 2.0 1 5.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL287868 AZAPROPHEN IC50 = 0.068 nM 10.17
CHEMBL26505 APROFENE IC50 = 11.0 nM 7.96
CHEMBL12980 QUINUCLIDINYL BENZILATE IC50 = 21.0 nM 7.68
CHEMBL70352 BENACTYZINE IC50 = 30.0 nM 7.52
CHEMBL517712 ATROPINE IC50 = 51.0 nM 7.29
CHEMBL353846 ADIPHENINE IC50 = 350.0 nM 6.46
CHEMBL9967 PIRENZEPINE IC50 = 2800.0 nM 5.55