Assay Detail
Binding
CHEMBL761548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against cGMP inhibited Phosphodiesterase 3, isolated from guinea pig ventricular tissue
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 4.67 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189 | MILRINONE | 4.0 | 1 | 6.14 |
| CHEMBL281244 | — | — | 1 | 5.46 |
| CHEMBL30941 | — | — | 1 | 5.30 |
| CHEMBL414613 | — | — | 1 | 5.29 |
| CHEMBL31715 | — | — | 1 | 5.22 |
| CHEMBL128691 | — | — | 1 | 5.07 |
| CHEMBL30619 | — | — | 1 | 4.85 |
| CHEMBL288547 | — | — | 1 | 4.75 |
| CHEMBL28562 | — | — | 1 | 4.70 |
| CHEMBL30406 | — | — | 1 | 4.54 |
| CHEMBL30671 | — | — | 1 | 4.52 |
| CHEMBL434590 | — | — | 1 | 4.41 |
| CHEMBL30733 | — | — | 1 | 4.38 |
| CHEMBL422437 | — | — | 1 | 4.37 |
| CHEMBL31743 | — | — | 1 | 4.36 |
| CHEMBL335843 | — | — | 1 | 4.35 |
| CHEMBL128461 | — | — | 1 | 4.24 |
| CHEMBL132107 | — | — | 1 | 4.24 |
| CHEMBL30407 | — | — | 1 | 4.19 |
| CHEMBL31877 | — | — | 1 | 4.17 |
| CHEMBL31063 | — | — | 1 | 4.17 |
| CHEMBL30379 | — | — | 1 | 4.01 |
| CHEMBL132346 | — | — | 1 | - |
| CHEMBL128788 | — | — | 1 | - |
| CHEMBL31795 | — | — | 1 | - |
| CHEMBL31530 | — | — | 1 | - |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL31439 | — | — | 1 | - |
| CHEMBL341519 | — | — | 1 | - |
| CHEMBL334988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189 | MILRINONE | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL281244 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL30941 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL414613 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL31715 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL128691 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL30619 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL288547 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL28562 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL30406 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL30671 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL434590 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL30733 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL422437 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL31743 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL335843 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL128461 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL132107 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL30407 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL31877 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL31063 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL30379 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL30966 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL130514 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL434822 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL132267 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL128146 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL288545 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL31773 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL131059 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL132273 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL132156 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL435363 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL132346 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL32673 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL31305 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL334988 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL341519 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL31439 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL63 | ROLIPRAM | IC50 | = | 242000.0 | nM | - |
| CHEMBL31530 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL31795 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL128788 | — | IC50 | > | 200000.0 | nM | - |