Compound Detail
CHEMBL422437
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Basic Information
| ChEMBL ID | CHEMBL422437 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YBGLUEMHERYXLN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
298.4
MW (Da)
3.85
ALogP
4
HBA
0
HBD
34.9
PSA (Ų)
0.72
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
| Phosphodiesterase 3 CHEMBL2094125 | IC50 | 4.37 | 4.37 | 43000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 4 | IC50 | = | 5000.0 | nM | 5.3 | Inhibitory activity against phosphodiesterase 4 isolated from guinea pig ventric... | 9767640 |
| Phosphodiesterase 3 | IC50 | = | 43000.0 | nM | 4.37 | Inhibitory activity against cGMP inhibited Phosphodiesterase 3, isolated from gu... | 9767640 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9767640 | 10.1021/jm981012m | Phosphodiesterase 4 | 1 |
| 9767640 | 10.1021/jm981012m | Phosphodiesterase 3 | 1 |
Data from ChEMBL 36 via Core Engine