Assay Detail
Binding
CHEMBL767077
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Inhibitory activity against phosphodiesterase 4 isolated from guinea pig ventricular tissue
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.70 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414613 | — | — | 1 | 7.25 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.50 |
| CHEMBL31530 | — | — | 1 | 6.40 |
| CHEMBL30619 | — | — | 1 | 6.22 |
| CHEMBL30733 | — | — | 1 | 6.22 |
| CHEMBL31063 | — | — | 1 | 6.22 |
| CHEMBL30406 | — | — | 1 | 6.22 |
| CHEMBL434590 | — | — | 1 | 6.16 |
| CHEMBL288545 | — | — | 1 | 6.10 |
| CHEMBL281244 | — | — | 1 | 6.08 |
| CHEMBL130514 | — | — | 1 | 6.05 |
| CHEMBL30379 | — | — | 1 | 6.05 |
| CHEMBL288547 | — | — | 1 | 6.00 |
| CHEMBL30407 | — | — | 1 | 6.00 |
| CHEMBL131059 | — | — | 1 | 6.00 |
| CHEMBL31439 | — | — | 1 | 6.00 |
| CHEMBL30966 | — | — | 1 | 5.96 |
| CHEMBL128461 | — | — | 1 | 5.96 |
| CHEMBL334988 | — | — | 1 | 5.89 |
| CHEMBL28562 | — | — | 1 | 5.85 |
| CHEMBL30941 | — | — | 1 | 5.82 |
| CHEMBL132107 | — | — | 1 | 5.82 |
| CHEMBL31715 | — | — | 1 | 5.82 |
| CHEMBL30671 | — | — | 1 | 5.64 |
| CHEMBL32673 | — | — | 1 | 5.64 |
| CHEMBL31305 | — | — | 1 | 5.60 |
| CHEMBL31743 | — | — | 1 | 5.57 |
| CHEMBL435363 | — | — | 1 | 5.52 |
| CHEMBL31773 | — | — | 1 | 5.40 |
| CHEMBL31795 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414613 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL31530 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL30619 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL30733 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL31063 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL30406 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL434590 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL288545 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL281244 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL130514 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL30379 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL31439 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL288547 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL30407 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL131059 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL30966 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL128461 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL334988 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL28562 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL31715 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL132107 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL30941 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL30671 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL32673 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL31305 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL31743 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL435363 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL31773 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL31795 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL132156 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL422437 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL341519 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL128691 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL335843 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL132346 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL31877 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL128146 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL128788 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL132273 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL434822 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL132267 | — | IC50 | > | 200000.0 | nM | - |