Assay Detail
Binding
CHEMBL761643
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Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.19 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143914 | — | — | 1 | 7.00 |
| CHEMBL291332 | — | — | 1 | 6.75 |
| CHEMBL141825 | — | — | 1 | 6.70 |
| CHEMBL57825 | — | — | 1 | 6.60 |
| CHEMBL56588 | — | — | 1 | 6.60 |
| CHEMBL57736 | — | — | 1 | 6.46 |
| CHEMBL56418 | — | — | 1 | 6.43 |
| CHEMBL142903 | — | — | 1 | 6.40 |
| CHEMBL417781 | — | — | 1 | 6.40 |
| CHEMBL294706 | — | — | 1 | 6.35 |
| CHEMBL300338 | — | — | 1 | 6.30 |
| CHEMBL295212 | — | — | 1 | 6.22 |
| CHEMBL57716 | — | — | 1 | 6.22 |
| CHEMBL142433 | — | — | 1 | 6.22 |
| CHEMBL58518 | — | — | 1 | 6.16 |
| CHEMBL57489 | — | — | 1 | 6.00 |
| CHEMBL293362 | — | — | 1 | 6.00 |
| CHEMBL57480 | — | — | 1 | 5.92 |
| CHEMBL301215 | — | — | 1 | 5.92 |
| CHEMBL57072 | — | — | 1 | 5.89 |
| CHEMBL60625 | — | — | 1 | 5.75 |
| CHEMBL418141 | — | — | 1 | 5.60 |
| CHEMBL56434 | — | — | 1 | 5.46 |
| CHEMBL56742 | — | — | 1 | 5.30 |
| CHEMBL142354 | — | — | 1 | - |
| CHEMBL143740 | — | — | 1 | - |
| CHEMBL141818 | — | — | 1 | - |
| CHEMBL60930 | — | — | 1 | - |
| CHEMBL143037 | — | — | 1 | - |
| CHEMBL143040 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143914 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL291332 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL141825 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL57825 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL56588 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL57736 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL56418 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL142903 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL417781 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL294706 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL300338 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL295212 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL57716 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL142433 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL58518 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL57489 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL293362 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL57480 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL301215 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL57072 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL60625 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL418141 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL56434 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL56742 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL142354 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL143740 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL141818 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL60930 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL143037 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL143040 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL60764 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL56932 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL141336 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL142786 | — | IC50 | > | 1000.0 | nM | - |