Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL142903

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(C)c1ccc2nc3ccc(C(=O)N[C@@H](C)CCCc4cccnc4)cn3c(=O)c2c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL142903
Phase Preclinical
Structure Type MOL
InChI Key DCNXKPFVMNEKDU-SFHVURJKSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

428.5
MW (Da)
4.51
ALogP
5
HBA
1
HBD
76.4
PSA (Ų)
0.44
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H28N4O2
MW 428.54
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -1.28

Activity Summary

IC50 1 meas. best 6.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Platelet-activating factor receptor
CHEMBL250
 IC50 6.4 6.4 400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Platelet-activating factor receptor IC50 = 400.0 nM 6.4 Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% ... 3339617

Literature References

PubMed DOI Target Context # Activities
3339617 10.1021/jm00397a034 Platelet-activating factor receptor 1
3339617 10.1021/jm00397a034 Cavia porcellus 1
3339617 10.1021/jm00397a034 ADMET 1
3339617 10.1021/jm00397a034 Canis familiaris 1

Data from ChEMBL 36 via Core Engine