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Assay Detail

CHEMBL761726

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Arteether, a new antimalarial drug: synthesis and antimalarial properties.
Brossi A, Venugopalan B, Dominguez Gerpe L, Yeh HJ, Flippen-Anderson JL, Buchs P, Luo XD, Milhous W, Peters W.
J Med Chem (1988) 31 : 645 -650
PubMed 3279208 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.64 8.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL307261 ARTENIMOL 3.0 1 8.74
CHEMBL207675 SODIUM ARESUNATE 1 8.66
CHEMBL301267 ARTEMOTIL 2.0 1 8.39
CHEMBL469416 ALPHA-ARTEETHER 1 8.38
CHEMBL566534 ARTEMETHER 4.0 1 8.35
CHEMBL269671 ARTEMISININ 3.0 1 7.98
CHEMBL76 CHLOROQUINE 4.0 1 7.96
CHEMBL416956 MEFLOQUINE 4.0 1 7.48
CHEMBL2368222 1 6.30
CHEMBL2368223 1 6.24
CHEMBL331309 DEOXYARTEMISININ 1 5.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL307261 ARTENIMOL IC50 = 1.83 nM 8.74
CHEMBL207675 SODIUM ARESUNATE IC50 = 2.18 nM 8.66
CHEMBL301267 ARTEMOTIL IC50 = 4.07 nM 8.39
CHEMBL469416 ALPHA-ARTEETHER IC50 = 4.18 nM 8.38
CHEMBL566534 ARTEMETHER IC50 = 4.49 nM 8.35
CHEMBL269671 ARTEMISININ IC50 = 10.53 nM 7.98
CHEMBL76 CHLOROQUINE IC50 = 10.84 nM 7.96
CHEMBL416956 MEFLOQUINE IC50 = 33.38 nM 7.48
CHEMBL2368222 IC50 = 506.04 nM 6.30
CHEMBL2368223 IC50 = 579.69 nM 6.24
CHEMBL331309 DEOXYARTEMISININ IC50 = 2863.08 nM 5.54