Assay Detail
Functional
CHEMBL761744
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Inhibition of human gel filtered platelet aggregation stimulated by ADP (10 mM)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Non-peptide glycoprotein IIb/IIIa inhibitors. 9. Centrally constrained alpha-sulfonamides are useful tools for exploring platelet receptor function
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.69 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33319 | — | — | 1 | 7.92 |
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | 7.75 |
| CHEMBL32960 | — | — | 1 | 7.57 |
| CHEMBL285821 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33319 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL916 | TIROFIBAN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL32960 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL285821 | — | IC50 | = | 31.0 | nM | 7.51 |