Assay Detail
Binding
CHEMBL761792
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Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.96 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127396 | — | — | 1 | 6.89 |
| CHEMBL127101 | — | — | 1 | 6.72 |
| CHEMBL125244 | — | — | 1 | 6.66 |
| CHEMBL338088 | — | — | 1 | 6.64 |
| CHEMBL123797 | — | — | 1 | 6.57 |
| CHEMBL127335 | — | — | 1 | 6.54 |
| CHEMBL151549 | — | — | 1 | 6.41 |
| CHEMBL123904 | — | — | 1 | 6.40 |
| CHEMBL125200 | — | — | 1 | 6.36 |
| CHEMBL541203 | — | — | 1 | 6.36 |
| CHEMBL126167 | — | — | 1 | 6.28 |
| CHEMBL435871 | — | — | 1 | 6.11 |
| CHEMBL125154 | — | — | 1 | 6.07 |
| CHEMBL124749 | — | — | 1 | 6.06 |
| CHEMBL341142 | — | — | 1 | 5.97 |
| CHEMBL339631 | — | — | 1 | 5.87 |
| CHEMBL147359 | — | — | 1 | 5.71 |
| CHEMBL340481 | — | — | 1 | 5.70 |
| CHEMBL126871 | — | — | 1 | 5.38 |
| CHEMBL340620 | — | — | 1 | 5.32 |
| CHEMBL419424 | — | — | 1 | 5.10 |
| CHEMBL339695 | — | — | 1 | 4.80 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | — | 1 | 4.72 |
| CHEMBL123798 | — | — | 1 | 4.41 |
| CHEMBL151728 | — | — | 1 | - |
| CHEMBL346886 | — | — | 1 | - |
| CHEMBL150423 | — | — | 1 | - |
| CHEMBL266608 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127396 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL127101 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL125244 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL338088 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL123797 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL127335 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL151549 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL123904 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL125200 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL541203 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL126167 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL435871 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL125154 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL124749 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL341142 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL339631 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL147359 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL340481 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL126871 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL340620 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL419424 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL339695 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL123798 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL151728 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL346886 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL150423 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL266608 | — | IC50 | > | 100000.0 | nM | - |