Assay Detail
Binding
CHEMBL761831
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphodiesterase 5 from bovine lung
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL3478) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.49 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137400 | — | — | 1 | 7.12 |
| CHEMBL68152 | — | — | 1 | 7.10 |
| CHEMBL140173 | — | — | 2 | 7.00 |
| CHEMBL140185 | — | — | 1 | 7.00 |
| CHEMBL137712 | — | — | 1 | 6.85 |
| CHEMBL344852 | — | — | 1 | 6.72 |
| CHEMBL71768 | — | — | 1 | 6.65 |
| CHEMBL343781 | — | — | 1 | 6.40 |
| CHEMBL343973 | — | — | 1 | 6.00 |
| CHEMBL139501 | — | — | 1 | 5.68 |
| CHEMBL136367 | — | — | 1 | 5.54 |
| CHEMBL343971 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137400 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL68152 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL140173 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL140185 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL137712 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL140173 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL344852 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL71768 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL343781 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL343973 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL139501 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL136367 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL343971 | — | IC50 | = | 3100.0 | nM | 5.51 |