Assay Detail
Functional
CHEMBL761869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentrations required to induce 50 percent polymerization of porcine brain-derived micro-tubule protein
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of highly potent analogues of epothilones B and D.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.06 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 6.17 |
| CHEMBL96172 | EPOTHILONE D | 2.0 | 1 | 6.06 |
| CHEMBL329993 | EPOTHILONE A | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL96172 | EPOTHILONE D | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL329993 | EPOTHILONE A | EC50 | = | 1120.0 | nM | 5.95 |