Assay Detail
Binding
CHEMBL761936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGF receptor autophosphorylation in mouse fibroblasts
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor (CHEMBL2096980) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.77 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62176 | — | — | 1 | 4.77 |
| CHEMBL292323 | — | — | 1 | - |
| CHEMBL304414 | — | — | 1 | - |
| CHEMBL62701 | — | — | 1 | - |
| CHEMBL60472 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62176 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL292323 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL304414 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL62701 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL60472 | — | IC50 | > | 100000.0 | nM | - |