Assay Detail
Functional
CHEMBL761987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against HIV-1 strain LAV in human peripheral blood mononuclear (PBM) cells.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
L-beta-(2S,4S)- and L-alpha-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 5.80 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148993 | — | — | 1 | 8.92 |
| CHEMBL359164 | TROXACITABINE | 2.0 | 1 | 8.70 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL359305 | — | — | 1 | 7.85 |
| CHEMBL300793 | — | — | 1 | 7.80 |
| CHEMBL347549 | — | — | 1 | 7.20 |
| CHEMBL304445 | — | — | 1 | 6.52 |
| CHEMBL146736 | — | — | 1 | 6.39 |
| CHEMBL348480 | — | — | 1 | 5.90 |
| CHEMBL345967 | — | — | 1 | 5.89 |
| CHEMBL355911 | — | — | 1 | 5.80 |
| CHEMBL356554 | — | — | 1 | 5.75 |
| CHEMBL38895 | — | — | 1 | 5.42 |
| CHEMBL423038 | — | — | 1 | 5.32 |
| CHEMBL346645 | — | — | 1 | 5.09 |
| CHEMBL148886 | — | — | 1 | 4.87 |
| CHEMBL39756 | — | — | 1 | 4.76 |
| CHEMBL356332 | — | — | 1 | 4.72 |
| CHEMBL358428 | — | — | 1 | 4.62 |
| CHEMBL149864 | — | — | 1 | 4.54 |
| CHEMBL150408 | — | — | 1 | 4.54 |
| CHEMBL149277 | — | — | 1 | 4.46 |
| CHEMBL263063 | — | — | 1 | 4.46 |
| CHEMBL147251 | — | — | 1 | 4.38 |
| CHEMBL151715 | — | — | 1 | 4.34 |
| CHEMBL147128 | — | — | 1 | 4.20 |
| CHEMBL146798 | — | — | 1 | - |
| CHEMBL151498 | — | — | 1 | - |
| CHEMBL150752 | — | — | 1 | - |
| CHEMBL151614 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148993 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL359164 | TROXACITABINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL359305 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL300793 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL347549 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL304445 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL146736 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL348480 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL345967 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL355911 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL356554 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL38895 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL423038 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL346645 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL148886 | — | EC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL39756 | — | EC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL356332 | — | EC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL358428 | — | EC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL149864 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL150408 | — | EC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL149277 | — | EC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL263063 | — | EC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL147251 | — | EC50 | = | 42120.0 | nM | 4.38 |
| CHEMBL151715 | — | EC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL147128 | — | EC50 | = | 62600.0 | nM | 4.20 |
| CHEMBL146798 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL151498 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL150752 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL151614 | — | EC50 | = | 101900.0 | nM | - |
| CHEMBL347305 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL147198 | — | EC50 | > | 100000.0 | nM | - |