Assay Detail
Functional
CHEMBL761988
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Effective concentration required to achieve 50% inhibition of HIV-1 IIIB multiplication in PBM (peripheral blood mononuclear) cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.42 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58213 | — | — | 1 | 6.75 |
| CHEMBL20610 | — | — | 1 | 6.34 |
| CHEMBL56328 | — | — | 1 | 5.68 |
| CHEMBL417953 | — | — | 1 | 5.54 |
| CHEMBL57161 | — | — | 1 | 5.37 |
| CHEMBL440482 | — | — | 1 | 5.29 |
| CHEMBL58914 | — | — | 1 | 5.26 |
| CHEMBL292392 | — | — | 1 | 4.40 |
| CHEMBL58653 | — | — | 1 | 4.12 |
| CHEMBL58891 | — | — | 1 | - |
| CHEMBL300607 | — | — | 1 | - |
| CHEMBL57313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58213 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL20610 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL56328 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL417953 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL57161 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL440482 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL58914 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL292392 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL58653 | — | EC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL58891 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL300607 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL57313 | — | EC50 | > | 100000.0 | nM | - |