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Assay Detail

CHEMBL761989

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration required to achieve 50% inhibition of HIV-2 D194 multiplication in PBM (peripheral blood mononuclear) cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase.
Pontikis R, Dollé V, Guillaumel J, Dechaux E, Note R, Nguyen CH, Legraverend M, Bisagni E, Aubertin AM, Grierson DS, Monneret C.
J Med Chem (2000) 43 : 1927 -1939
PubMed 10821705 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 5.24 6.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20610 1 6.37
CHEMBL417953 1 5.33
CHEMBL56328 1 5.10
CHEMBL58653 1 4.17
CHEMBL58914 1 -
CHEMBL57161 1 -
CHEMBL58213 1 -
CHEMBL300607 1 -
CHEMBL440482 1 -
CHEMBL292392 1 -
CHEMBL57313 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20610 EC50 = 430.0 nM 6.37
CHEMBL417953 EC50 = 4700.0 nM 5.33
CHEMBL56328 EC50 = 8000.0 nM 5.10
CHEMBL58653 EC50 = 68000.0 nM 4.17
CHEMBL58914 EC50 > 25000.0 nM -
CHEMBL57161 EC50 > 50000.0 nM -
CHEMBL58213 EC50 > 33000.0 nM -
CHEMBL300607 EC50 > 100000.0 nM -
CHEMBL440482 EC50 > 25000.0 nM -
CHEMBL292392 EC50 > 100000.0 nM -
CHEMBL57313 EC50 > 100000.0 nM -