Assay Detail
Binding
CHEMBL762089
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Binding affinity against Oxytocin receptor was determined in rat uterine membrane using radioligand [3H]oxytocin
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacology of novel analogues of oxytocin and deaminooxytocin: directed methods for the construction of disulfide and trisulfide bridges in peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.64 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435716 | DEMOXYTOCIN | 2.0 | 1 | 9.05 |
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 8.77 |
| CHEMBL353396 | DEAMINOOXYTOCIN TRISULFIDE | — | 1 | 8.52 |
| CHEMBL352836 | OXYTOCIN TRISULFIDE | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435716 | DEMOXYTOCIN | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL395429 | OXYTOCIN | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL353396 | DEAMINOOXYTOCIN TRISULFIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL352836 | OXYTOCIN TRISULFIDE | Ki | = | 6.0 | nM | 8.22 |