Assay Detail
Binding
CHEMBL762233
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Compound was evaluated for its dissociation constant (Kd) to guinea pig myometrial Oxytocin receptor
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of oxytocin antagonists containing conformationally constrained amino acids in position 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.67 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264208 | — | — | 1 | 8.22 |
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 8.17 |
| CHEMBL157988 | — | — | 1 | 8.10 |
| CHEMBL405165 | — | — | 1 | 7.42 |
| CHEMBL2110163 | — | — | 1 | 6.43 |
| CHEMBL2110297 | — | — | 1 | 5.72 |
| CHEMBL2371240 | — | — | 2 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264208 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL395429 | OXYTOCIN | Kd | = | 6.7 | nM | 8.17 |
| CHEMBL157988 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL405165 | — | Kd | = | 37.6 | nM | 7.42 |
| CHEMBL2110163 | — | Kd | = | 369.5 | nM | 6.43 |
| CHEMBL2110297 | — | Kd | = | 1917.7 | nM | 5.72 |
| CHEMBL2371240 | — | Kd | = | 8545.0 | nM | 5.07 |
| CHEMBL2371240 | — | Kd | = | 57450.0 | nM | 4.24 |