Assay Detail
Binding
CHEMBL762413
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Inhibitory activity against Prostaglandin G/H synthase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.48 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118462 | — | — | 1 | 4.85 |
| CHEMBL119841 | — | — | 1 | 4.30 |
| CHEMBL118944 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118462 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL119841 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL118944 | — | IC50 | = | 51000.0 | nM | 4.29 |