Assay Detail
Binding
CHEMBL762444
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Inhibition of Prostaglandin G/H synthase in intact RBL-1 cell line
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.65 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1562610 | MECLOFENAMATE SODIUM | 4.0 | 1 | 7.00 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.30 |
| CHEMBL433287 | — | — | 1 | 6.26 |
| CHEMBL295829 | OXAMETACIN | 2.0 | 1 | 5.96 |
| CHEMBL65050 | — | — | 1 | 5.96 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.70 |
| CHEMBL303199 | — | — | 1 | 5.57 |
| CHEMBL65490 | — | — | 1 | 5.28 |
| CHEMBL65431 | — | — | 1 | 5.24 |
| CHEMBL292707 | IBUPROXAM | 2.0 | 1 | 5.00 |
| CHEMBL65535 | — | — | 1 | 4.82 |
| CHEMBL65430 | — | — | 1 | 4.70 |
| CHEMBL303307 | — | — | 1 | - |
| CHEMBL15770 | SULINDAC | 4.0 | 1 | - |
| CHEMBL65130 | — | — | 1 | - |
| CHEMBL65759 | — | — | 1 | - |
| CHEMBL65299 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1562610 | MECLOFENAMATE SODIUM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL433287 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL295829 | OXAMETACIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL65050 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL303199 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL65490 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL65431 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL292707 | IBUPROXAM | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL65535 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL65430 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL303307 | — | IC50 | - | nM | - | |
| CHEMBL15770 | SULINDAC | IC50 | - | nM | - | |
| CHEMBL65130 | — | IC50 | < | 200.0 | nM | - |
| CHEMBL65759 | — | IC50 | - | nM | - | |
| CHEMBL65299 | — | IC50 | - | nM | - |