Assay Detail
Binding
CHEMBL762447
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Inhibitory activity against cyclooxygenase in rat basophilic leukemia cells using prostaglandin G/H synthase assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.42 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8562 | — | — | 1 | 6.82 |
| CHEMBL149278 | — | — | 1 | 6.52 |
| CHEMBL356510 | — | — | 1 | 6.05 |
| CHEMBL148922 | — | — | 1 | 6.05 |
| CHEMBL151309 | — | — | 1 | 5.96 |
| CHEMBL150170 | — | — | 1 | 5.92 |
| CHEMBL12302 | — | — | 1 | 5.82 |
| CHEMBL146786 | — | — | 1 | 5.47 |
| CHEMBL356843 | — | — | 1 | 5.40 |
| CHEMBL146701 | — | — | 1 | 5.34 |
| CHEMBL148962 | — | — | 1 | 5.16 |
| CHEMBL149451 | — | — | 1 | 5.13 |
| CHEMBL151847 | — | — | 1 | 5.05 |
| CHEMBL347975 | — | — | 1 | 5.03 |
| CHEMBL151433 | — | — | 1 | 5.00 |
| CHEMBL356014 | — | — | 1 | 4.94 |
| CHEMBL151608 | — | — | 1 | 4.92 |
| CHEMBL148850 | — | — | 1 | 4.86 |
| CHEMBL150804 | — | — | 1 | 4.85 |
| CHEMBL149945 | — | — | 1 | 4.80 |
| CHEMBL150783 | — | — | 1 | 4.66 |
| CHEMBL150717 | — | — | 1 | - |
| CHEMBL151987 | — | — | 1 | - |
| CHEMBL347053 | — | — | 1 | - |
| CHEMBL359369 | — | — | 1 | - |
| CHEMBL357141 | — | — | 1 | - |
| CHEMBL149448 | — | — | 1 | - |
| CHEMBL12594 | E-5110 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8562 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL149278 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL356510 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL148922 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL151309 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL150170 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL12302 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL146786 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL356843 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL146701 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL148962 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL149451 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL151847 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL347975 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL151433 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL356014 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL151608 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL148850 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL150804 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL149945 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL150783 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL150717 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL151987 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL347053 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL359369 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL357141 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL149448 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL12594 | E-5110 | IC50 | < | 1000.0 | nM | - |