Assay Detail
Binding
CHEMBL762448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of prostaglandin G/H synthase in intact rat basophilic leukemia cells stimulated with the calcium ionophore A-23187
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.11 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295739 | — | — | 1 | 7.92 |
| CHEMBL12594 | E-5110 | — | 1 | 7.40 |
| CHEMBL16434 | — | — | 1 | 7.08 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | 4.0 | 1 | 7.00 |
| CHEMBL8562 | — | — | 1 | 6.82 |
| CHEMBL16048 | — | — | 1 | 6.80 |
| CHEMBL2111719 | — | — | 1 | 6.48 |
| CHEMBL113138 | — | — | 1 | 6.47 |
| CHEMBL49008 | — | — | 1 | 6.46 |
| CHEMBL109745 | DARBUFELONE MESYLATE | -1.0 | 1 | 6.41 |
| CHEMBL280226 | — | — | 1 | 6.22 |
| CHEMBL48568 | — | — | 1 | 6.19 |
| CHEMBL277721 | — | — | 1 | 6.10 |
| CHEMBL49249 | — | — | 1 | 6.10 |
| CHEMBL325065 | — | — | 1 | 6.09 |
| CHEMBL326108 | — | — | 1 | 5.96 |
| CHEMBL47223 | — | — | 1 | 5.77 |
| CHEMBL278246 | — | — | 1 | 5.72 |
| CHEMBL15904 | — | — | 1 | 5.68 |
| CHEMBL113211 | — | — | 1 | 5.62 |
| CHEMBL109501 | — | — | 1 | 5.46 |
| CHEMBL113908 | — | — | 1 | 5.35 |
| CHEMBL48814 | — | — | 1 | 5.34 |
| CHEMBL325315 | — | — | 1 | 5.34 |
| CHEMBL111438 | — | — | 1 | 5.29 |
| CHEMBL112733 | — | — | 1 | 5.02 |
| CHEMBL112720 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295739 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL12594 | E-5110 | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL16434 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL8562 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL16048 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2111719 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL113138 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL49008 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL109745 | DARBUFELONE MESYLATE | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL280226 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL48568 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL277721 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL49249 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL325065 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL326108 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL47223 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL278246 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL15904 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL113211 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL109501 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL113908 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL48814 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL325315 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL111438 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL112733 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL112720 | — | IC50 | = | 10000.0 | nM | 5.00 |