Assay Detail
Binding
CHEMBL762553
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human platelet phosphodiesterase 2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.99 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50378 | EHNA | — | 1 | 5.30 |
| CHEMBL97546 | — | — | 1 | 5.22 |
| CHEMBL94931 | — | — | 1 | 5.05 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50378 | EHNA | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL97546 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL94931 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL98350 | LY-294002 | IC50 | = | 40000.0 | nM | 4.40 |