Assay Detail
Binding
CHEMBL762675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of low Km cAMP phosphodiesterase PDE III of human lung
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Phosphodiesterase; PDE3 & PDE4 (CHEMBL2095153) ↗| Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
Publication
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.13 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19224 | PAPAVERINE | 3.0 | 1 | 5.18 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 5.16 |
| CHEMBL18701 | RO-201724 | — | 1 | 5.04 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | - |
| CHEMBL150764 | BUFROLIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19224 | PAPAVERINE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL18701 | RO-201724 | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 230000.0 | nM | - |
| CHEMBL150764 | BUFROLIN | IC50 | = | 280000.0 | nM | - |