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Assay Detail

CHEMBL762745

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]- oxytocin binding to rat uterine Oxytocin receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Oxytocin receptor (CHEMBL3996)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications.
Freidinger RM, Williams PD, Tung RD, Bock MG, Pettibone DJ, Clineschmidt BV, DiPardo RM, Erb JM, Garsky VM, Gould NP.
J Med Chem (1990) 33 : 1843 -1845
PubMed 2163451 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 7.43 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2372927 1 8.80
CHEMBL301708 1 8.38
CHEMBL54443 1 8.28
CHEMBL300103 1 8.23
CHEMBL127686 1 8.14
CHEMBL52176 1 8.11
CHEMBL300642 1 8.09
CHEMBL292579 1 7.77
CHEMBL2372926 1 7.31
CHEMBL2372928 1 7.31
CHEMBL339118 1 7.08
CHEMBL297725 1 6.85
CHEMBL339493 1 6.31
CHEMBL52813 1 5.85
CHEMBL2372932 1 4.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2372927 Ki = 1.6 nM 8.80
CHEMBL301708 Ki = 4.2 nM 8.38
CHEMBL54443 Ki = 5.3 nM 8.28
CHEMBL300103 Ki = 5.9 nM 8.23
CHEMBL127686 Ki = 7.3 nM 8.14
CHEMBL52176 Ki = 7.8 nM 8.11
CHEMBL300642 Ki = 8.1 nM 8.09
CHEMBL292579 Ki = 17.0 nM 7.77
CHEMBL2372926 Ki = 49.0 nM 7.31
CHEMBL2372928 Ki = 49.0 nM 7.31
CHEMBL339118 Ki = 83.0 nM 7.08
CHEMBL297725 Ki = 140.0 nM 6.85
CHEMBL339493 Ki = 490.0 nM 6.31
CHEMBL52813 Ki = 1400.0 nM 5.85
CHEMBL2372932 Ki = 12000.0 nM 4.92