Assay Detail
Binding
CHEMBL762831
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphodiesterase type 5 (PDE5) of human platelets
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.41 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278354 | — | — | 1 | 9.32 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.80 |
| CHEMBL22906 | — | — | 1 | 8.28 |
| CHEMBL283122 | — | — | 1 | 8.28 |
| CHEMBL25391 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278354 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL22906 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL283122 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL25391 | — | IC50 | = | 44.0 | nM | 7.36 |