Compound Detail
CHEMBL25391
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Basic Information
| ChEMBL ID | CHEMBL25391 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NMWJDNXABGLWBW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
320.4
MW (Da)
3.67
ALogP
5
HBA
2
HBD
83.9
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 7.36 | 7.36 | 44.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 44.0 | nM | 7.36 | Inhibition of phosphodiesterase type 5 (PDE5) of human platelets | 10753463 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10753463 | 10.1021/jm000081+ | Unchecked | 4 |
| 10753463 | 10.1021/jm000081+ | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 10753463 | 10.1021/jm000081+ | Phosphodiesterase 3 and 5 (PDE3 and PDE5) | 1 |
Data from ChEMBL 36 via Core Engine