Assay Detail
Functional
CHEMBL762987
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Inhibitory concentration against Plasmodium falciparum W2 infected erythrocytes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.49 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 9.10 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 8.10 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.92 |
| CHEMBL416958 | — | — | 1 | 7.43 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.00 |
| CHEMBL37404 | — | — | 1 | 6.93 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.84 |
| CHEMBL34804 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL416958 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL170 | QUININE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL37404 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL34804 | — | IC50 | = | 277.0 | nM | 6.56 |