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Assay Detail

CHEMBL763063

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Prostaglandin G/H synthase of ram seminal vesicle microsomes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Tissue Seminal vesicle
Confidence 5 — Multiple protein complex / RNA
Curated By Expert

Target

Prostaglandin G/H synthase (cyclooxygenase) (CHEMBL2111358)
Type PROTEIN FAMILY
Organism Ovis aries

Publication

Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids.
Hagmann WK, Dorn CP, Frankshun RA, O'Grady LA, Bailey PJ, Rackham A, Dougherty HW.
J Med Chem (1986) 29 : 1436 -1441
PubMed 3488405 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.05 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL284705 1 7.00
CHEMBL33378 1 7.00
CHEMBL6 INDOMETHACIN 4.0 1 6.52
CHEMBL33987 1 6.52
CHEMBL34003 1 5.89
CHEMBL285188 1 5.85
CHEMBL32961 1 5.85
CHEMBL32990 1 5.75
CHEMBL286802 1 5.16
CHEMBL33814 1 5.00
CHEMBL33527 1 -
CHEMBL418217 1 -
CHEMBL34741 1 -
CHEMBL32218 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL284705 IC50 = 100.0 nM 7.00
CHEMBL33378 IC50 = 100.0 nM 7.00
CHEMBL6 INDOMETHACIN IC50 = 300.0 nM 6.52
CHEMBL33987 IC50 = 300.0 nM 6.52
CHEMBL34003 IC50 = 1300.0 nM 5.89
CHEMBL285188 IC50 = 1400.0 nM 5.85
CHEMBL32961 IC50 = 1400.0 nM 5.85
CHEMBL32990 IC50 = 1800.0 nM 5.75
CHEMBL286802 IC50 = 7000.0 nM 5.16
CHEMBL33814 IC50 = 10000.0 nM 5.00
CHEMBL33527 IC50 > 100000.0 nM -
CHEMBL418217 IC50 - nM -
CHEMBL34741 IC50 - nM -
CHEMBL32218 IC50 > 100000.0 nM -