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Assay Detail

CHEMBL763142

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against human quiescent cell proline dipeptidase (QPP) enzyme
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Dipeptidyl peptidase 2 (CHEMBL3976)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.
Caldwell CG, Chen P, He J, Parmee ER, Leiting B, Marsilio F, Patel RA, Wu JK, Eiermann GJ, Petrov A, He H, Lyons KA, Thornberry NA, Weber AE.
Bioorg Med Chem Lett (2004) 14 : 1265 -1268
PubMed 14980678 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 5.39 6.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL279944 1 6.39
CHEMBL423108 1 6.22
CHEMBL23110 1 6.18
CHEMBL22359 1 6.16
CHEMBL22294 1 6.09
CHEMBL23176 1 6.05
CHEMBL25211 1 5.96
CHEMBL277635 1 5.96
CHEMBL280658 1 5.72
CHEMBL283368 1 5.70
CHEMBL23223 1 5.55
CHEMBL22545 1 5.52
CHEMBL416008 1 5.50
CHEMBL277693 1 5.46
CHEMBL22679 1 5.39
CHEMBL23924 1 5.35
CHEMBL278558 1 5.30
CHEMBL23660 1 5.30
CHEMBL23891 1 5.28
CHEMBL23051 1 5.21
CHEMBL23979 1 5.19
CHEMBL431885 1 5.12
CHEMBL277193 1 5.09
CHEMBL281178 1 5.08
CHEMBL25437 1 5.06
CHEMBL283309 1 5.03
CHEMBL22310 1 4.92
CHEMBL281561 1 4.92
CHEMBL278393 1 4.72
CHEMBL22511 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL279944 IC50 = 410.0 nM 6.39
CHEMBL423108 IC50 = 600.0 nM 6.22
CHEMBL23110 IC50 = 660.0 nM 6.18
CHEMBL22359 IC50 = 690.0 nM 6.16
CHEMBL22294 IC50 = 810.0 nM 6.09
CHEMBL23176 IC50 = 900.0 nM 6.05
CHEMBL25211 IC50 = 1100.0 nM 5.96
CHEMBL277635 IC50 = 1100.0 nM 5.96
CHEMBL280658 IC50 = 1900.0 nM 5.72
CHEMBL283368 IC50 = 2000.0 nM 5.70
CHEMBL23223 IC50 = 2800.0 nM 5.55
CHEMBL22545 IC50 = 3000.0 nM 5.52
CHEMBL416008 IC50 = 3200.0 nM 5.50
CHEMBL277693 IC50 = 3500.0 nM 5.46
CHEMBL22679 IC50 = 4100.0 nM 5.39
CHEMBL23924 IC50 = 4500.0 nM 5.35
CHEMBL278558 IC50 = 5000.0 nM 5.30
CHEMBL23660 IC50 = 5000.0 nM 5.30
CHEMBL23891 IC50 = 5200.0 nM 5.28
CHEMBL23051 IC50 = 6100.0 nM 5.21
CHEMBL23979 IC50 = 6400.0 nM 5.19
CHEMBL431885 IC50 = 7500.0 nM 5.12
CHEMBL277193 IC50 = 8100.0 nM 5.09
CHEMBL281178 IC50 = 8300.0 nM 5.08
CHEMBL25437 IC50 = 8800.0 nM 5.06
CHEMBL283309 IC50 = 9400.0 nM 5.03
CHEMBL22310 IC50 = 12000.0 nM 4.92
CHEMBL281561 IC50 = 12000.0 nM 4.92
CHEMBL278393 IC50 = 19000.0 nM 4.72
CHEMBL22511 IC50 = 20000.0 nM 4.70
CHEMBL23879 IC50 = 21000.0 nM 4.68
CHEMBL23880 IC50 = 25000.0 nM 4.60
CHEMBL23981 IC50 = 38000.0 nM 4.42