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Assay Detail

CHEMBL763208

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Human progesterone receptor (hPR) agonist activity in T47D human breast cancer cell line
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type T47D
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.
Zhi L, Tegley CM, Pio B, West SJ, Marschke KB, Mais DE, Jones TK.
Bioorg Med Chem Lett (2000) 10 : 415 -418
PubMed 10743938 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 6.27 8.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL103 PROGESTERONE 4.0 1 8.74
CHEMBL335992 1 6.61
CHEMBL131855 1 6.30
CHEMBL334890 1 6.24
CHEMBL132192 1 6.16
CHEMBL133656 1 5.99
CHEMBL132195 1 5.85
CHEMBL132193 1 5.75
CHEMBL133661 1 5.58
CHEMBL538158 1 5.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL103 PROGESTERONE EC50 = 1.8 nM 8.74
CHEMBL335992 EC50 = 245.0 nM 6.61
CHEMBL131855 EC50 = 500.0 nM 6.30
CHEMBL334890 EC50 = 580.0 nM 6.24
CHEMBL132192 EC50 = 700.0 nM 6.16
CHEMBL133656 EC50 = 1024.0 nM 5.99
CHEMBL132195 EC50 = 1400.0 nM 5.85
CHEMBL132193 EC50 = 1800.0 nM 5.75
CHEMBL133661 EC50 = 2650.0 nM 5.58
CHEMBL538158 EC50 = 3500.0 nM 5.46